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|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide from the C-terminus of the Flt-1 precursor of human origin|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Western Blot (WB)||5-10 µg/mL|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-16493 targets Flt-1 in Western blot applications and shows reactivity with mouse, Rat, and Human samples.
The PA5-16493 immunogen is a synthetic peptide from the C-terminus of the Flt-1 precursor of human origin.
Flt-1/vascular endothelial growth factor receptor 1 (VEGFR1), a cell membrane receptor kinase, is a high affinity receptor for vascular endothelial growth factor and is putatively involved in the growth of endothelial cells and angiogenesis. It contains seven immunoglobulin like sequences in the extracellular domain and exhibits sequence similarity to Flk-1 and Flt-4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
PDGFR-β (+) perivascular cells from infantile hemangioma display the features of mesenchymal stem cells and show stronger adipogenic potential in vitro and in vivo.
PA5-16493 was used in immunocytochemistry to isolate and characterize PDGFR-beta(+) perivascular cells from infantile hemangioma
|Yuan SM,Guo Y,Zhou XJ,Shen WM,Chen HN||International journal of clinical and experimental pathology (7:2861)||2014|
Mesenchymal stem cells in infantile hemangioma reside in the perivascular region.
PA5-16493 was used in immunocytochemistry to test if MSCs in hemangioma also reside in the perivascular region
|Yuan SM,Chen RL,Shen WM,Chen HN,Zhou XJ||Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society (15:5)||2012|
GVHD after allogeneic haematopoietic SCT for AML: angiogenesis, vascular endothelial growth factor and VEGF receptor expression in the BM.
PA5-16493 was used in immunohistochemistry to study the roles of angiogenesis and the VEGF/VEGFR system in acute GVHD
|Medinger M,Tichelli A,Bucher C,Halter J,Dirnhofer S,Rovo A,Passweg J,Tzankov A||Bone marrow transplantation (48:715)||2013|
Prognostic utility of angiogenesis and hypoxia effectors in patients with operable squamous cell cancer of the larynx.
PA5-16493 was used in immunohistochemistry to study the prognostic value of angiogenesis and hypoxia effectors in patients with operable squamous cell cancer of the larynx
|Pentheroudakis G,Nicolaou I,Kotoula V,Fountzilas E,Markou K,Eleftheraki AG,Fragkoulidi A,Karasmanis I,Tsigka A,Angouridakis N,Vlachtsis K,Nikolaou A,Pavlidis N,Fountzilas G||Oral oncology (48:709)||2012|
Clinical impact of phosphorylated signal transducer and activator of transcription 3, epidermal growth factor receptor, p53, and vascular endothelial growth factor receptor 1 expression in resected adenocarcinoma of lung by using tissue microarray.
PA5-16493 was used in immunohistochemistry to investigate the expression of specific genes in resected adenocarcinoma of lung
|Kim HS,Park YH,Lee J,Ahn JS,Kim J,Shim YM,Kim JH,Park K,Han J,Ahn MJ||Cancer (116:676)||2010|
embryonic receptor kinase 2; FLT-1; FMS-like tyrosine kinase 1; Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; vascular endothelial growth factor receptor 1; vascular endothelial growth factor receptor-1; vascular permeability factor receptor
AI323757; Emrk2; FLT; FLT-1; FLT1; FRT; sFlt1; VEGFR-1; VEGFR1