|Immunohistochemistry (Paraffin) (IHC (P))||14 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 17 amino acid peptide from N-terminal extracellular domain of human Frizzled-6.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
Percent identity with other species by BLAST analysis: Human (100%) Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Bovine, Horse (94%).
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Frizzled 6; frizzled 6, seven transmembrane spanning receptor; Frizzled family receptor 6; Frizzled homolog 6; Frizzled-6; FZ-6; FZ6; FZD6; HFZ6; NDNC10; seven transmembrane helix receptor
Gene Aliases: FZ-6; FZ6; FZD6; HFZ6; NDNC10
UniProt ID: (Human) O60353
Entrez Gene ID: (Human) 8323
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