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|Tested species reactivity||Human, Non-human primate|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 1-50 of human GPR109B.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||10 µg/ml|
|Western Blot (WB)||0.5-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-41622 detects GPR109B in chimpanzee and human samples.
This antibody is predicted to react with canine and hamster based on sequence homology.
GPR109B is a membrane protein belonging to family 1 of G protein-coupled receptor (GPCR) is homologous to GPR109A. GPR109B, a potential 7 transmembrane-spanning receptor, shows a significant homology to B2 bradykinin receptor and to thrombin receptor. GPR109B mediates the anti-lipolytic and lipid-lowering effect of nicotinic acid by acting as a nicotinic acid receptor and results in a G protein-mediated decrease in cAMP levels and hence are promising targets for future pharmacotherapy. It is known to show highest expression in spleen followed by lymphocytes and adipose tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
G protein-coupled receptor 109B; G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B; GTP-binding protein; HM74; hydroxy-carboxylic acid receptor 3; niacin receptor 2; nicotinic acid receptor 2; putative chemokine receptor
GPR109B; HCA3; HCAR3; HM74; HM74B; NIACR2; Puma-g; PUMAG