|Tested species reactivity||Bovine, Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (379 IEGQSPFRGRKEKVKREE 396) of G Protein-Coupled Receptor Kinase 5 protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||20 µg/ml|
|Western Blot (WB)||0.5-4 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
GRK5 is a 590 amino acid protein belonging to the G protein-coupled receptor kinase family and consisting of AGC-kinase C-terminal, protein kinase and RGS domains. It phosphorylates the activated forms of G protein-coupled receptors, thus initiating their deactivation. It also phosphorylates the human substance P receptor and plays a role in regulating the motility of polymorphonuclear leukocytes (PMNs). It contains a membrane binding motif consisting of a group of hydrophobic amino acids that mediates its plasma membrane (PM) localization. GRK5 is expressed in heart, placenta, lung, skeletal muscle, brain, liver, pancreas and kidney.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.