|Tested species reactivity||Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Fusion protein within the cytoplasmic loop of rat GABAA receptor alpha 1 subunit.|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.01% BSA, 50% glycerol|
|Contains||0.09% sodium azide|
|Storage Conditions||4°C or -20°C if preferred|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Predicted to react with bovine, chicken, dog, human and monkey based on sequence homology.
In Western blot, this antibody detects a band at ~51 kDa in rat forebrain lysate.
Gamma-aminobutyric acid (GABA) A receptors are GABA gated chloride channels, which are important mediators of neuronal inhibition in the mammalian central nervous system. Activation of the GABAA site results in increased intracellular chloride concentration and hyperpolarization of the cell. GABAA receptors are pentameric structures assembled from a family of distinct subunits. At least fourteen distinct subunits have been identified, which show distinct patterns of temporal and spatial expression. GABAA receptors may be modulated by several drug types including benzodiazepines and barbiturates, and by phosphorylation by protein kinase C (PKC) and protein kinase A (PKA). The GABA-A receptors are important targets for a variety of drugs such as benzodiazepines, barbiturates, steroids, anaesthetics and convulsants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.