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Invitrogen
GABARAP Recombinant Rabbit Monoclonal Antibody (23GB5490)
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FIGURE: 1 / 3
GABARAP Antibody (MA5-52866) in ICC/IF
Immunocytochemistry analysis of GABARAP in HepG2 cells. Sample was incubated with GABARAP monoclonal (Product # MA5-52866) antibody at a dilution of 1:1,000, followed by DAPI and Alexa Fluor 647. Protein abundance based on laser intensity and smart gain: Low. Scale bar: 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-52866
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB5490
Immunogen
A synthesized peptide derived from human GABARAP (10-64AA).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.33 mg/mL
Amount
33 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Gamma-aminobutyric acid (GABA) is the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing in the central nervous system. It has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. GABARAP (GABAA receptor-associated protein) links GABAA receptors to the cytoskeleton and may play a role in intracellular transport of GABAA receptors and its interaction with the cytoskeleton. GABARAP belongs to the MAP1 or ATG8 like family and recent studies show that MAPK15/ERK8 is acting through interaction with ATG8 family proteins to regulate autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; FLJ25768; GABA(A) receptor-associated protein; GABA-A receptor-associated protein; GABARAP; GABARAP a; gamma-aminobutyric acid reseptor associated protein; MGC120154; MGC120155; unnamed protein product
Gene Aliases: ATG8A; GABARAP-a; MM46
UniProt ID: (Human) O95166, (Mouse) Q9DCD6, (Rat) P60517
Entrez Gene ID: (Human) 11337, (Mouse) 56486, (Rat) 58974
autophagosome assembly
microtubule cytoskeleton organization
mitophagy
cellular response to nitrogen starvation
extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of Rac protein signal transduction
reticulophagy
autophagosome maturation
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
positive regulation of protein K48-linked ubiquitination
negative regulation of TORC1 signaling
positive regulation of lysosome organization
protein targeting
chemical synaptic transmission
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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