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OriGene
GAD1 Monoclonal Antibody (OTI3G9), TrueMAB™
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
TA500329
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI3G9
Immunogen
Full length human recombinant protein of human GAD1 produced in HEK293T cell.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.46 mg/mL
Amount
46 µg
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67: the predominant GAD-67 form and the minor GAD-25 form.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 67 kDa glutamic acid decarboxylase; FLJ45882; GAD; GAD 1; GAD 67; GAD67 short splice variant; glutamate decarboxylase 1 (brain 67kDa) isoform GAD1_1; glutamate decarboxylase 1 (brain 67kDa) isoform GAD1_2; glutamate decarboxylase 1 (brain 67kDa) isoform GAD1_3; glutamate decarboxylase 1 (brain, 67kDa); OTTHUMP00000041055; unnamed protein product
Gene Aliases: CPSQ1; DEE89; GAD; GAD-67; SCP
UniProt ID: (Human) Q99259
Entrez Gene ID: (Human) 2571
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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