Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.
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Protein Aliases: GADD34; Growth arrest and DNA damage-inducible protein GADD34; growth arrest and DNA-damage-inducible 34; Myeloid differentiation primary response protein MyD116 homolog; protein phosphatase 1; Protein phosphatase 1 regulatory subunit 15A; protein phosphatase 1, regulatory (inhibitor) subunit 15A; protein phosphatase 1, regulatory subunit 15A; regulatory (inhibitor) subu
Gene Aliases: GADD34; PPP1R15A
UniProt ID: (Human) O75807
Entrez Gene ID: (Human) 23645