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|Tested species reactivity||Chicken, Human, Mouse, Rabbit, Reptile, Rat|
|Published species reactivity||Rat, Mouse|
|Host / Isotype||Mouse / IgG2a, kappa|
|Immunogen||Purified, full length GAP-43 protein (both phosphorylated & unphosphorylated forms).|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Fezf1 is required for penetration of the basal lamina by olfactory axons to promote olfactory development.
33-5000 was used in immunohistochemistry to investigate the molecular mechanisms that regulate the penetration of pioneer axons of the olfactory receptor neurons into the central nervous system basal lamina.
|Watanabe Y,Inoue K,Okuyama-Yamamoto A,Nakai N,Nakatani J,Nibu K,Sato N,Iiboshi Y,Yusa K,Kondoh G,Takeda J,Terashima T,Takumi T||The Journal of comparative neurology (515:565)||2009|
|Mouse||1:2000||Gene discovery in genetically labeled single dopaminergic neurons of the retina.||Gustincich S,Contini M,Gariboldi M,Puopolo M,Kadota K,Bono H,LeMieux J,Walsh P,Carninci P,Hayashizaki Y,Okazaki Y,Raviola E||Proceedings of the National Academy of Sciences of the United States of America (101:5069)||2004|
|Mouse||Not Cited||In vitro development of mouse embryonic stem cells lacking JNK/stress-activated protein kinase-associated protein 1 (JSAP1) scaffold protein revealed its requirement during early embryonic neurogenesis.||Xu P,Yoshioka K,Yoshimura D,Tominaga Y,Nishioka T,Ito M,Nakabeppu Y||The Journal of biological chemistry (278:48422)||2003|
|Rat||Not Cited||Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes.||Baltensperger K,Kozma LM,Cherniack AD,Klarlund JK,Chawla A,Banerjee U,Czech MP||Science (New York, N.Y.) (260:1950)||1993|
axonal membrane protein GAP-43; B-50; brain abundant, membrane attached signal protein 2; calmodulin-binding protein P-57; growth accentuating protein 43; growth-associated protein 43; nerve growth-related peptide GAP43; neural phosphoprotein B-50; neuromodulin; neuron growth-associated protein 43; neuron growth-associated protein 43 protein F1; PP46; protein F1
B-50; Basp2; GAP-43; GAP43; PP46