GARS is a glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. This protein is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. The protein has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis.
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Protein Aliases: 18.104.22.168; AP-4-A synthetase; Ap4A synthetase; Charcot-Marie-Tooth neuropathy 2D; Charcot-Marie-Tooth neuropathy, neuronal type, D; Diadenosine tetraphosphate synthetase; EC 22.214.171.124; GARTF; glycine tRNA ligase; Glycine--tRNA ligase; Glycyl-tRNA synthetase; GlyRS; MGC47764; PAIS; PGFT; PRGS; storage granule protein 23
Gene Aliases: CMT2D; DSMAV; GARS; Gena201; GENA202; GlyRS; HMN5; Nmf249; RGD1559871; Sgrp23; SMAD1