Western blot analysis of MA1-028 detects a prominent ~50 kDa protein in GATA3 expressing SH-SY5Y cells. The signal is enhanced in nuclear extracts due to enrichment of GATA3. This antibody has also been successfully tested in IP, IHC and Immunofluorescence applications.
MA1-028 can be used for immunofluoresence analysis of Gata3 in human ESC lines.
MA1-028 was successfully used in western blotting analysis of GATA3 in breast cancer cell lines.
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. GATA3 also regulates luminal epithelial cell differentiation in the mammary gland and is mutated in breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GATA Binding Protein 3; GATA-Binding Factor 3; GATA-binding protein 3; HDR; Trans-Acting T-Cell-Specific Transcription Factor GATA-3
Gene Aliases: Gata-3; GATA3; HDR; HDRS; jal