MA5-15641 targets GATA3 in IHC and WB applications and shows reactivity with Human samples.
The MA5-15641 immunogen is purified recombinant fragment of human GATA3 expressed in E. Coli.
MA5-15641 detects GATA3 which has a predicted molecular weight of approximately 48kDa.
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. (provided by RefSeq) Tissue specificity: T-cells and endothelial cells RD: GATA-3 belongs to the GATA family of transcription factors, which bind to the consensus DNA sequence (A/T) GATA (A/G) to control diverse tissue-specific programs of gene expression and morphogenesis. It is widely expressed in mesodermal- and endodermal-derived tissues. GATA-3 has been shown to be an essential regulator for immune cell function, sympathetic neuron development, and the maintenance of the differentiated state in epithelial cells.
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Protein Aliases: GATA-binding factor 3; GATA3; HDR; MGC2346; MGC5199; MGC5445; Trans-acting T-cell-specific transcription factor GATA-3
Gene Aliases: GATA3; HDR; HDRS
UniProt ID: (Human) P23771
Entrez Gene ID: (Human) 2625