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Invitrogen
GBP1 Recombinant Rabbit Monoclonal Antibody (23GB5530)
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FIGURE: 1 / 3
GBP1 Antibody (MA5-52876) in ICC/IF
Immunocytochemistry analysis of GBP1 in HepG2 cells. Sample was incubated with GBP1 monoclonal (Product # MA5-52876) antibody at a dilution of 1:1,000, followed by DAPI and Alexa Fluor 647. Protein abundance based on laser intensity and smart gain: Low. Scale bar: 20 μm.
Product Details
MA5-52876
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB5530
Immunogen
A synthesized peptide derived from human GBP1 (530-592AA).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
GBP1 or guanlyate binding protein 1 is a 68 kDa GTPase and member of the GTPase1 family of molecules. GBP1 expression is induced by Interferon g as well as other inflammatory cytokines including IL-1a, IL-1b and TNF-a. Induction of GBP1 expression by poly I:C, a prototypical TLR3 ligand, as well as GBP1 expression dependency on NF-kB and IFNa response elements implicate TLR pathway involvement. Inversely proportional expression of GBP1 and MMP-1 as well as other related molecules to adhesion and migration show a clear functional role of GBP1 in suppressing angiogenesis and migration especially of endothelial cells. As a regulatory molecule it is centrally involved in signal transduction of inflammatory and cell migration networks.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GBP-1; GTP-binding protein 1; Guanine nucleotide-binding protein 1; guanylate binding protein 1, interferon-inducible, 67kDa; guanylate nucleotide binding protein 1; Guanylate-binding protein 1; huGBP-1; interferon-gamma-inducible protein MAG-1; Interferon-induced guanylate-binding protein 1; unnamed protein product
Gene Aliases: Gbp-1; GBP1; hGBP1; Mag-1; Mpa-1; Mpa1
UniProt ID: (Human) P32455
Entrez Gene ID: (Human) 2633, (Mouse) 14468
nucleotide binding
lipopolysaccharide binding
actin binding
GTPase activity
obsolete small monomeric GTPase activity
guanosine-diphosphatase activity
protein binding
GTP binding
hydrolase activity
GDP binding
enzyme binding
cytokine binding
spectrin binding
identical protein binding
protein homodimerization activity
Hsp90 protein binding
GMP binding
heterotrimeric G-protein
immune system process
negative regulation of interleukin-2 production
defense response to bacterium
defense response to protozoan
innate immune response
regulation of calcium-mediated signaling
negative regulation of T cell receptor signaling pathway
protein maturation
defense response to virus
cytolysis in other organism
negative regulation of ERK1 and ERK2 cascade
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
protein localization to vacuole
positive regulation of pyroptotic inflammatory response
non-canonical inflammasome complex assembly
negative regulation of substrate adhesion-dependent cell spreading
regulation of protein localization to plasma membrane
negative regulation of protein localization to plasma membrane
cellular response to interferon-beta
adhesion of symbiont to host
defense response to Gram-positive bacterium
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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