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GBX2 Monoclonal Antibody (4B11)

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GBX2 Antibody in Western Blot (WB) — GBX2 monoclonal antibody (M09), clone 4B11 Western Blot analysis of GBX2 expression in NIH/3T3 (Cat # L018V1).

Product Details

H00002637-M09

Applications	Tested Dilution	Publications
Western Blot (WB)	1-5 µg/mL	-
ELISA (ELISA)	10 µg/mL	-

Product Specifications
Species Reactivity	Human, Mouse
Host/Isotype	Mouse / IgG2a, kappa
Class	Monoclonal
Type	Antibody
Clone	4B11
Immunogen	GBX2 (NP_001476, 141 a.a. approximately 230 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	See Label
Purification	Affinity chromatography
Storage buffer	PBS, pH 7.4
Contains	no preservative
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Sequence of this protein is as follows: AEALQADAED GKGFLAKEGS LLAFSAAETV QASLVGAVRG QGKDESKVED DPKGKEESFS LESDVDYSSD DNLTGQAAHK EEDPGHALEE *

Target Information

Altered expression of GBX2, part of the homeobox-containing human family of DNA-binding transcription factors, is associated with therapy failure and death in patients with multiple types of cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Gastrulation and brain-specific homeobox protein 2; Homeobox protein GBX-2; Stimulated by retinoic acid gene 7 protein

Gene Aliases: D130058E05Rik; Gbx-2; GBX2; MMoxA; Stra7

UniProt ID: (Human) P52951, (Mouse) P48031

Entrez Gene ID: (Human) 2637, (Mouse) 14472

Molecular Function: homeodomain transcription factor

patterning of blood vessels neural crest cell migration transcription from RNA polymerase II promoter nervous system development axon guidance cerebellum development midbrain-hindbrain boundary morphogenesis rhombomere 2 development thalamus development forebrain neuron development cerebellar granule cell precursor proliferation inner ear morphogenesis positive regulation of transcription from RNA polymerase II promoter autonomic nervous system development transcription, DNA-templated regulation of transcription, DNA-templated cell proliferation hindbrain development midbrain-hindbrain boundary development tube morphogenesis

Process(es)

RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription factor binding transcription factor activity, sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding