|ELISA (ELISA)||Assay dependent|
|Western Blot (WB)||1 ug/ml|
|ELISA (ELISA)||See 1 publications below|
|Tested Species reactivity||Bovine|
|Published species reactivity||Bovine|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Bacterial expressed full length GCAP-2.|
|Storage buffer||PBS with 1mg/ml BSA|
|Contains||0.05% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
MA1-725 detects GCAP-2 from bovine samples. This antibody is specific for GCAP-2 and does not react with other isotypes.
MA1-725 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~23 kDa protein representing GCAP-2 protein in bovine samples.
The MA1-725 immunogen is bacterial expressed full length GCAP-2.
Guanylate cyclase-activating proteins (GCAPs) are calcium binding proteins that belong to the calmodulin superfamily. GCAPs without calcium are responsible for activation of photoreceptor guanylate cyclase during light adaptation. Studies have shown that the addition or subtraction of Ca2+ results in major conformational changes and the activation/deactivation of GCAP-1 and GCAP-2.
It has been demonstrated that both GCAP-1 and 2 act on guanylate cyclase similarly and have approximately 50% homology between the two forms. GCAP-1 is predominantly localized in the photoreceptor outer segments, while GCAP-2 is found in retina samples.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GCAP 2; Guanylate cyclase activator 1B; Guanylate Cyclase-Activating Protein 2; Guanylin 2; Guanylyl cyclase-activating protein 2; GUCA 2; Retinal guanylyl cyclase activator protein p24
Gene Aliases: BOS_21473; GCAP-2; GCAP2; GUCA1B
UniProt ID: (Bovine) P51177
Entrez Gene ID: (Bovine) 286851
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