Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, Huh7, Hep3B, HepG2.
Predicted reactivity: Mouse (97%), Rat (97%), Zebrafish (86%), Xenopus laevis (87%), Cat (96%), Sheep (97%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
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Protein Aliases: ATP:D-hexose 6-phosphotransferase; Glucokinase; glucokinase (hexokinase 4); hexokinase D, pancreatic isozyme; Hexokinase type IV; Hexokinase-4; Hexokinase-D; HK IV; HK4; MEKKK 2
Gene Aliases: FGQTL3; GCK; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2
UniProt ID: (Human) P35557
Entrez Gene ID: (Human) 2645