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Invitrogen
GCN4 Chimeric Recombinant Rabbit Monoclonal Antibody (C11L34)
Product Details
MA5-47958
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Yeast
Host/Isotype
Rabbit
/ IgG, lambda
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
C11L34
Immunogen
Biotinylated GCN4-peptide (HLENEVARLKK).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3074402
Product Specific Information
Specificity: This antibody binds to the HLENEVARLKK peptide from the leucine-zipper domain of the S. cerevisiae GCN4 transcriptional activator with picomolar affinity.
Target Information
GCN4 is a transcription factor protein in yeast that plays a crucial role in the regulation of genes involved in amino acid biosynthesis, such as HIS4, HIS7, HIS3, ARG1, ARG3, ARG4, and ARG5,6. The protein contains a basic leucine zipper (bZIP) domain that enables it to bind to specific DNA sequences, thereby regulating the transcription of target genes. The protein is also involved in the regulation of other cellular processes, including stress response and nutrient signaling, such as GSH1, YAP1, and TRX2. Its structure is composed of a dimeric coiled-coil domain, which allows for protein-protein interactions, and a DNA-binding bZIP domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Amino acid biosynthesis regulatory protein; General control protein GCN4; General control transcription factor GCN4
Gene Aliases: AAS101; AAS3; ARG9; GCN4; YEL009C
UniProt ID: (Baker's yeast) P03069
Entrez Gene ID: (Baker's yeast) 856709
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
basic leucine zipper transcription factor
negative regulation of transcription from RNA polymerase II promoter
nitrogen catabolite activation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
autophagy
cellular amino acid biosynthetic process
positive regulation of autophagy
negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels
positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
positive regulation of transcription initiation from RNA polymerase II promoter
positive regulation of cellular response to amino acid starvation
protein localization to nuclear periphery
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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