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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Synthetic peptide derived from the C-terminal region of the human PSMA.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PMSA (FOLH1) is a type II transmembrane glycoprotein belonging to the M28 peptidase family. Three functionally distinct proteins are encoded, including folylpoly-gamma-glutamate carboxypeptidase in the intestine, N-acetylated alpha-linked acidic dipeptidase 1 in the brain, and prostate-specific membrane antigen in the prostate. A mutation in the intestinal form may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. The form expressed in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. The prostate form is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
mGCP, GCP2, FGCP, NAALAD1, GCPII, NAALAdase, GIG27, FOLH, PSMA, PSM
N-acetylated alpha-linked acidic dipeptidase 1, N-acetylated-alpha-linked acidic dipeptidase I, NAALADase I, cell growth-inhibiting gene 27 protein, folylpoly-gamma-glutamate carboxypeptidase, glutamate carboxylase II, glutamate carboxypeptidase 2, glutamate carboxypeptidase II, membrane glutamate carboxypeptidase, prostate specific membrane antigen variant F, pteroylpoly-gamma-glutamate carboxypeptidase, FGCP, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, mGCP