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Proteintech
GDF5 Recombinant Rabbit Monoclonal Antibody (240944E5)
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Product Details
83988-4-RR
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
240944E5
Immunogen
GDF5 fusion protein Ag6238
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SFLLKKARE PGPPREPKEP FRPPPITPHE YMLSLYRTLS DADRKGGNSS VKLEAGLANT ITSFIDKGQD DRGPVVRKQR YVFDISALEK DGLLGAELRI LRKKPSDTAK PAAPGGGRAA QLKLSSCPSG RQPASLLDVR SVPGLDGSGW EVFDIWKLFR NFKNSAQLCL ELEAWERGRA VDLRGLGFDR AARQVHEKAL FLVFGRTKKR DLFFNEIKAR SGQDDKTVYE YLFSQRRKRR APLATRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR
Target Information
GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Hunter-Thompson type dwarfism and in Grebe Syndrome, which is characterized by short stature, extra digits, and short and deformed extremities. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino acid signal peptide and a 354 amino acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP-14; Bone morphogenetic protein 14; brachypodism; Cartilage-derived morphogenetic protein 1; cartilage-derived morphogenetic protein-1; CDMP-1; GDF-5; Growth/differentiation factor 5; H-GDF-5; LAP-4; Lipopolysaccharide-associated protein 4; LPS-associated protein 4; Radotermin
Gene Aliases: BDA1C; BMP-14; BMP14; Bp; brp; Cdmp-1; CDMP1; Gdf-5; GDF5; LAP-4; LAP4; OS5; SYM1B; SYNS2
UniProt ID: (Human) P43026, (Mouse) P43027
Entrez Gene ID: (Human) 8200, (Mouse) 14563
chondrocyte differentiation
transforming growth factor beta receptor signaling pathway
SMAD protein import into nucleus
cell-cell signaling
positive regulation of pathway-restricted SMAD protein phosphorylation
embryonic limb morphogenesis
positive regulation of BMP signaling pathway
negative regulation of chondrocyte differentiation
positive regulation of chondrocyte differentiation
forelimb morphogenesis
hindlimb morphogenesis
growth
regulation of multicellular organism growth
regulation of apoptotic process
regulation of MAPK cascade
negative regulation of neuron apoptotic process
positive regulation of neuron differentiation
cell development
negative regulation of epithelial cell proliferation
SMAD protein signal transduction
chondroblast differentiation
mitophagy in response to mitochondrial depolarization
negative regulation of mesenchymal cell apoptotic process
transmembrane receptor protein serine/threonine kinase signaling pathway
BMP signaling pathway
cartilage development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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