GEF-H1 activates Rho GTPases by promoting the exchange of GDP and GTP. Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. GEF-H1 may be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Alternatively spliced transcript variants encoding different isoforms have been identified.
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Protein Aliases: GEF-H1; GEFH1; Guanine nucleotide exchange factor H1; LFP40; Microtubule-regulated Rho-GEF; Proliferating cell nucleolar antigen p40; Rho guanine nucleotide exchange factor 2; Rho/Rac guanine nucleotide exchange factor (GEF) 2; Rho/Rac guanine nucleotide exchange factor 2
Gene Aliases: ARHGEF2; GEF; GEF-H1; GEFH1; KIAA0651; LFP40; P40
UniProt ID: (Human) Q92974
Entrez Gene ID: (Human) 9181