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|Tested species reactivity||Human|
|Published species reactivity||Mouse|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||protein glial fibrillary acidic protein|
|Conjugate||Alexa Fluor® 488|
|Storage buffer||PBS, pH 7.2, with 0.1% BSA|
|Contains||5mM sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||1-10 ug/ml|
|Immunofluorescence (IF)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Glial fibrillary acidic protein (GFAP) is a member of the class III intermediate filament protein family. It is heavily, and specifically, expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In addition, neural stem cells frequently strongly express GFAP. Antibodies to GFAP are therefore very useful as markers of astrocytic cells. In addition many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Dual-energy precursor and nuclear erythroid-related factor 2 activator treatment additively improve redox glutathione levels and neuron survival in aging and Alzheimer mouse neurons upstream of reactive oxygen species.
A-21294 was used in immunocytochemistry to investigate the role of reactive oxygen species in neuron loss, aging, and Alzheimer's disease.
|Ghosh D,LeVault KR,Brewer GJ||Neurobiology of aging (35:179)||2014|
Vesicular stomatitis virus infects resident cells of the central nervous system and induces replication-dependent inflammatory responses.
A-21294 was used in flow cytometry to investigate the effect of vesicular stomatitis virus infection on CNS system and inflammation induction
|Chauhan VS,Furr SR,Sterka DG,Nelson DA,Moerdyk-Schauwecker M,Marriott I,Grdzelishvili VZ||Virology (400:187)||2010|
GFAP; Glial fibrillary acidic protein