MA1-06701 detects GFAP in human samples.
MA1-06701 has sucessfully been used in Western blotting and immunohistochemistry procedures. By Western blot MA1-06605 detects a ~55 kDa protein representing GFAP.
The MA1-06701 immunogen is glial fibrillary acidic protein from brain.
GFAP (Glial fibrillary acidic protein) is a member of the class III intermediate filament protein family. GFAP is heavily, and specifically, expressed in astrocytes and certain astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In addition, neural stem cells strongly express GFAP. Antibodies to GFAP are very useful as markers of astrocytic cells. In addition, many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes. GFAP is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing of the GFAP gene results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ45472; GFAP; Glial fibrillary acidic protein
Gene Aliases: ALXDRD; GFAP
UniProt ID: (Human) P14136
Entrez Gene ID: (Human) 2670