|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||synthetic peptide TALRVKNKPLGPAG, corresponding to amino acids 369-382 of Human GFR alpha 1.|
|Contains||0.02% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-32476 detects GFR alpha 1 from human, rat, mouse samples.
PA1-32476 has been successfully used in Western blot applications.
The PA1-32476 immunogen is: Synthetic peptide: TALRVKNKPLGPAG, corresponding to amino acids 369-382 of Human GFR alpha 1.
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.