|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A peptide corresponding to amino acids from 347 to 360 of murine GFR alpha 3.|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||10 µg/ml|
|Western Blot (WB)||0.5 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is mouse heart tissue lysate.
PA5-19875 can be used with blocking peptide PEP-0010.
Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFR-a and Ret receptor tyrosine kinase GFRbeta. Following the findings of GFR-a-1 and -2, a novel receptor in GFR-a family was identified very recently from human and mouse and designated GFR-a-3. GFR-a-3 binds persephin, thus, persephin, GFR-a-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.