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Alomone Labs, LTD
GFRAL (extracellular) Polyclonal Antibody
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FIGURE: 1 / 2
GFRAL (extracellular) Antibody (ANT-029-200UL) in IHC (F)
Expression of GFRAL in rat nucleus of the solitary tract. Immunohistochemical staining of perfusion-fixed frozen rat brain sections using Anti-GFRAL (extracellular) Antibody (#ANT-029) (1:200), followed by goat anti-rabbit-AlexaFluor-488. A. GFRAL immunoreactivity (green) appears in cells lining the wall of the 4th ventricle (down pointing arrow) and in neurons in the nucleus of the solitary tract (horizont... View More
Product Details
ANT-029-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide HEPPFWDTPLNHG, corresponding to amino acid residues 92-104 of rat SLC10A4. Extracellular, N-terminus.
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunogen sequence: HEPPFWDTPLNHG
Reconstitution: 25 uL, 50 uL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GDNF family receptor alpha-like; GDNF receptor alpha-like
Gene Aliases: AY457637; Gfral; Gral; RGD1565220
UniProt ID: (Mouse) Q6SJE0, (Rat) D3ZB94
Entrez Gene ID: (Mouse) 404194, (Rat) 501023
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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