This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: GLI-Kruppel family member GLI1; Glioma-associated oncogene; glioma-associated oncogene 1; glioma-associated oncogene homolog 1 (zinc finger protein); Oncogene GLI; Zinc finger protein GLI1
Gene Aliases: GLI; GLI1
UniProt ID: (Human) P08151
Entrez Gene ID: (Human) 2735
Molecular Function: DNA-binding transcription factor