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This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: bA500G10.4; FLJ11864; glutaredoxin 4; Glutaredoxin-3; PICOT; PKC interacting cousin of thioredoxin; PKC-interacting cousin of thioredoxin; PKC-theta-interacting protein; PKCq-interacting protein; testicular tissue protein Li 75; thioredoxin-like 2; Thioredoxin-like protein 2
Gene Aliases: GLRX3; GLRX4; GRX3; GRX4; HUSSY-22; PICOT; TXNL2; TXNL3
UniProt ID: (Human) O76003, (Mouse) Q9CQM9
Entrez Gene ID: (Human) 10539, (Mouse) 30926
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