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|Tested species reactivity||Human, Rat|
|Published species reactivity||Rat, Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide derived from C-terminal of human GLUT-1|
|Storage buffer||PBS, pH 7.6, with 0.2% BSA|
|Contains||15mM sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:200|
|Western Blot (WB)||2-4 ug/ ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-16793 targets GLUT-1 in IHC (P), WB, and IF applications and shows reactivity with Human and Rat samples.
The PA5-16793 immunogen is a synthetic peptide derived from C-terminal of human GLUT-1.
Glucose is fundamental to the metabolism of mammalian cells. Several glucose transporter protein (Glut) isoforms have been identified and shown to function in response to insulin and IGF-1 induced signaling. GLUT-1 is detectable in many human tissues including those of the colon, lung, stomach, esophagus, and breast. GLUT-1 immunoreactivity in some cancers, including trans carcinoma of the urinary bladder, has been associated with aggressive behavior.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia.
PA5-16793 was used in western blot to study the effect of allopurinol treatment during hypoxia
|Sun Y,George J,Rocha S||PloS one (10:null)||2015|
The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability.
PA5-16793 was used in western blot to study the regulation of HIF1-alpha mRNA stability by P-body USP52/PAN2
|Bett JS,Ibrahim AF,Garg AK,Kelly V,Pedrioli P,Rocha S,Hay RT||The Biochemical journal (451:185)||2013|
Subfield-specific neurovascular remodeling in the entorhino-hippocampal-organotypic slice culture as a response to oxygen-glucose deprivation and excitotoxic cell death.
PA5-16793 was used in western blot to study the effects of oxygen/glucose deprivation and excitotoxic neuronal death on neurovascular changes using an organotypic entorhino-hippocampal culture model
|Chip S,Nitsch C,Wellmann S,Kapfhammer JP||Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (33:508)||2013|
Sphingosine kinase 1: a new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells.
PA5-16793 was used in western blot to investigate the role of sphingosine kinase 1 during hypoxia in human cancer cells
|Ader I,Brizuela L,Bouquerel P,Malavaud B,Cuvillier O||Cancer research (68:8635)||2008|
Gpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical wnt signaling.
PA5-16793 was used in immunohistochemistry - paraffin section to evaluate the role of Gpr124 in CNS angiogenesis and blood-brain barrier integrity
|Zhou Y,Nathans J||Developmental cell (31:248)||2014|
Monitoring hypoxia and vasculature during bevacizumab treatment in a murine colorectal cancer model.
PA5-16793 was used in immunohistochemistry to use a murine model of colorectal cancer to study the effects of bevacizumab therapy on tumor hypoxia and vascular density
|Heijmen L,Ter Voert EG,Punt CJ,Heerschap A,Oyen WJ,Bussink J,Sweep CG,Laverman P,Span PN,de Geus-Oei LF,Boerman OC,van Laarhoven HW||Contrast media & molecular imaging (9:237)||2014|
Kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon: ultrastructural observation and immunohistochemistry staining reveal the trapping of blood components.
PA5-16793 was used in immunohistochemistry to report on a case of kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon in an infant
|Yuan SM,Hong ZJ,Chen HN,Shen WM,Zhou XJ||Ultrastructural pathology (37:452)||2013|
Immunohistochemical expression of GLUT-1 and Ki-67 in chronic plaque psoriasis.
PA5-16793 was used in immunohistochemistry to study the expression and biological significance of Glut1 and Ki67 in chronic plaque psoriasis
|Abdou AG,Maraee AH,Eltahmoudy M,El-Aziz RA||The American Journal of dermatopathology (35:731)||2013|
18F-fluorodeoxyglucose positron emission tomography/computed tomography and the relationship between fluorodeoxyglucose uptake and the expression of hypoxia-inducible factor-1α, glucose transporter-1 and vascular endothelial growth factor in thymic epithelial tumours.
PA5-16793 was used in immunohistochemistry to study the the clinical value of the relationships between fluorodeoxyglucose-PET/CT and HIF-1alpha, Glut1 and VEGF in thymic epithelial tumors
|Toba H,Kondo K,Sadohara Y,Otsuka H,Morimoto M,Kajiura K,Nakagawa Y,Yoshida M,Kawakami Y,Takizawa H,Kenzaki K,Sakiyama S,Bando Y,Tangoku A||European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (44:e105)||2013|
Synchrotron microbeam radiation therapy induces hypoxia in intracerebral gliosarcoma but not in the normal brain.
PA5-16793 was used in immunohistochemistry to study the differential effects of synchrotron microbeam radiation therapy on intracerebral gliosarcoma and normal brain tissue and the significance for tumor hypoxia
|Bouchet A,Lemasson B,Christen T,Potez M,Rome C,Coquery N,Le Clec'h C,Moisan A,Bräuer-Krisch E,Leduc G,Rémy C,Laissue JA,Barbier EL,Brun E,Serduc R||Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (108:143)||2013|
Congenital melanocytic nevus with features of hybrid schwannoma/perineurioma.
PA5-16793 was used in immunohistochemistry to report on a case of congenital melanocytic nevus
|Wang L,Wang G,Gao T||Journal of cutaneous pathology (40:497)||2013|
Transforming growth factor-β1 may be a key mediator of the fibrogenic properties of neural cells in leprosy.
PA5-16793 was used in immunohistochemistry to study the role of TGF-beta1 in driving Schwann cell phenotypic reprogramming and fibrogenesis in response to Mycobacterium leprae
|Petito RB,Amadeu TP,Pascarelli BM,Jardim MR,Vital RT,Antunes SL,Sarno EN||Journal of neuropathology and experimental neurology (72:351)||2013|
Low-grade fibromyxoid sarcoma with prominent giant rosettes and heterotopic ossification.
PA5-16793 was used in immunohistochemistry to report on a case of low-grade fibromyxoid sarcoma displaying unusual clinicopathology
|Hisaoka M,Matsuyama A,Aoki T,Sakamoto A,Yokoyama K||Pathology, research and practice (208:557)||2012|
FDG-PET is a good biomarker of both early response and acquired resistance in BRAFV600 mutant melanomas treated with vemurafenib and the MEK inhibitor GDC-0973.
PA5-16793 was used in immunohistochemistry to study FDG uptake as a biomarker of early response and acquired resistance in BRAFV600 mutant melanomas treated with vemurafenib and a MEK inhibitor
|Baudy AR,Dogan T,Flores-Mercado JE,Hoeflich KP,Su F,van Bruggen N,Williams SP||EJNMMI research (2:null)||2012|
Differences in metabolism between adeno- and squamous cell non-small cell lung carcinomas: spatial distribution and prognostic value of GLUT1 and MCT4.
PA5-16793 was used in immunohistochemistry to study the differential immunohistochemical expression of Glut1 and MCT4 in adeno and squamous cell non-small cell lung carcinoma and the metabolic significance
|Meijer TW,Schuurbiers OC,Kaanders JH,Looijen-Salamon MG,de Geus-Oei LF,Verhagen AF,Lok J,van der Heijden HF,Rademakers SE,Span PN,Bussink J||Lung cancer (Amsterdam, Netherlands) (76:316)||2012|
Correlation between FDG uptake by PET/CT and the expressions of glucose transporter type 1 and hexokinase II in cervical cancer.
PA5-16793 was used in immunohistochemistry to study the relationship between labelled glucose uptake and Glut1 and hexokinase II expression in lymph nodes of patients with cervical cancer
|Tong SY,Lee JM,Ki KD,Choi YJ,Seol HJ,Lee SK,Huh CY,Kim GY,Lim SJ||International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (22:654)||2012|
Biological factors, tumor growth kinetics, and survival after metastasectomy for pulmonary melanoma.
PA5-16793 was used in immunohistochemistry to investigate the prognostic markers for the development of pulmonary melanoma metastases after metastasectomy
|Lee JH,Gulec SA,Kyshtoobayeva A,Sim MS,Morton DL||Annals of surgical oncology (16:2834)||2009|
The Warburg effect is genetically determined in inherited pheochromocytomas.
PA5-16793 was used in immunohistochemistry to investigate the mechanism of Warburg effect regulation in pheochromocytomas
|Favier J,Brière JJ,Burnichon N,Rivière J,Vescovo L,Benit P,Giscos-Douriez I,De Reyniès A,Bertherat J,Badoual C,Tissier F,Amar L,Libé R,Plouin PF,Jeunemaitre X,Rustin P,Gimenez-Roqueplo AP||PloS one (4:null)||2009|
Correlation between FDG uptake and glucose transporter type 1 expression in neuroendocrine tumors of the lung.
PA5-16793 was used in immunohistochemistry to investigate the association between FDG uptake and glucose transporter type 1
|Song YS,Lee WW,Chung JH,Park SY,Kim YK,Kim SE||Lung cancer (Amsterdam, Netherlands) (61:54)||2008|
Targeting Glut1-overexpressing MDA-MB-231 cells with 2-deoxy-D-g1ucose modified SPIOs.
PA5-16793 was used in immunocytochemistry to study the ability of 2-deoxy-D-glucose-modified SPIOs to target Glut1-overexpressing MDA-MB-231 tumor cells
|Shan XH,Hu H,Xiong F,Gu N,Geng XD,Zhu W,Lin J,Wang YF||European journal of radiology (81:95)||2012|
Human monocyte-derived hemangioma-like endothelial cells: evidence from an in vitro study.
PA5-16793 was used in immunocytochemistry to investigate the pathogenesis of hemangioma
|Jia J,Huang X,Zhang WF,Zhao YF||Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology (17:212)||2008|
choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity); erythrocyte/brain; facilitated glucose transporter member 1; glucose transporter type 1; glucose transporter type 1, erythrocyte/brain; GLUT-1; hepG2 glucose transporter; human T-cell leukemia virus (I and II) receptor; receptor for HTLV-1 and HTLV-2; solute carrier family 2; solute carrier family 2 (facilitated glucose transporter), member 1; Solute carrier family 2 a 1 (facilitated glucose transporter) brain; solute carrier family 2, facilitated glucose transporter member 1; solute carrier family 2, member 1
CSE; DYT17; DYT18; DYT9; EIG12; GLUT; GLUT-1; GLUT1; GLUT1DS; GLUTB; GTG1; Gtg3; HTLVR; PED; RATGTG1; SDCHCN; SLC2A1