MA5-17176 targets SLC2A4 in FACS, ICC, IHC, IF and WB applications and shows reactivity with Human and Mouse samples.
The MA5-17176 immunogen is purified recombinant fragment of human SLC2A4 (amino acids: 224-353 ) expressed in E. Coli.
MA5-17176 detects SLC2A4 which has a predicted molecular weight of approximately 54.8kDa.
This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM).
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Protein Aliases: Glucose transporter type 4, insulin-responsive; GLUT-4; GT2; insulin-responsive glucose transporter type 4; solute carrier family 2 (facilitated glucose transporter), member 4; Solute carrier family 2, facilitated glucose transporter member 4
Gene Aliases: Glut-4; GLUT4; SLC2A4