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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • GNAO1 Antibodies

          Invitrogen

          GNAO1 Polyclonal Antibody

          Advanced Verification
          2 Published Figures
          3 References
          View all (12) GNAO1 antibodies

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          Datasheet
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          Datasheet
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          Cite GNAO1 Polyclonal Antibody

          • Antibody Testing Data (10)
          • Published Figures (2)
          • Advanced Verification (1)
          GNAO1 Antibody in Immunocytochemistry (ICC/IF)
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          GNAO1 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 13

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          GNAO1 Antibody (PA5-30044) in ICC/IF

          Immunocytochemistry-Immunofluorescence analysis of GNAO1 was performed in DIV9 rat E18 primary hippocampal neuron cells fixed in 4% paraformaldehyde at RT for 15 min. Green: GNAO1 Polyclonal Antibody (Product # PA5-30044) diluted at 1:500. Red: beta Tubulin 3/ Tuj1, stained by beta Tubulin 3/ Tuj1 antibody. Blue: Fluoroshield with DAPI. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
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          View Product

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          GNAO1 Antibody in Immunocytochemistry (ICC/IF)
          GNAO1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          GNAO1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          GNAO1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          GNAO1 Antibody in Immunohistochemistry (Frozen) (IHC (F))
          GNAO1 Antibody in Western Blot (WB)
          GNAO1 Antibody in Western Blot (WB)
          GNAO1 Antibody in Western Blot (WB)
          GNAO1 Antibody in Western Blot (WB)
          GNAO1 Antibody in Immunoprecipitation (IP)
          GNAO1 Antibody in Western Blot (WB)
          GNAO1 Antibody in Western Blot (WB)
          GNAO1 Antibody

          Product Details

          PA5-30044

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:20,000
          View 3 publications 3 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:100-1:1,000
          -

          Immunohistochemistry (Frozen) (IHC (F))

          1:100-1:1,000
          -

          Immunocytochemistry (ICC/IF)

          1:100-1:1,000
          -

          Immunoprecipitation (IP)

          1:100-1:500
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Mouse

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Recombinant protein encompassing a sequence within the center region of human GNAO1. The exact sequence is proprietary.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7, with 1% BSA, 20% glycerol

          Contains

          0.01% thimerosal

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2547518

          Product Specific Information

          Recommended positive controls: U87-MG, SK-N-SH, IMR32, SK-N-AS, mouse brain, mouse lung, rat brain, rat lung.

          Predicted reactivity: Mouse (97%), Rat (98%), Xenopus laevis (98%), Chicken (98%), Rhesus Monkey (100%), Bovine (98%).

          Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

          Target Information

          Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively.

          ⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: DKFZp686O0962; G alpha o; GNAO 1; Go alpha; GO2-q chimeric G-protein; GTP-binding protein alpha o; GTP-binding protein alpha-o subunit; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; guanine nucleotide binding protein, alpha O polypeptide 1; Guanine nucleotide-binding protein G(o) subunit alpha; guanine nucleotide-binding regulatory protein 2

          View more View less

          Gene Aliases: alphaO; AW050213; EIEE17; G-ALPHA-o; Galphao; Gna0; GNAO; GNAO1; HLA-DQB1; RATBPGTPC

          View more View less

          UniProt ID: (Human) P09471, (Rat) P59215, (Mouse) P18872

          View more View less

          Entrez Gene ID: (Human) 2775, (Rat) 50664, (Mouse) 14681

          View more View less

          Function(s)
          GTPase activity signal transducer activity GTP binding G-protein beta/gamma-subunit complex binding G-protein coupled serotonin receptor binding mu-type opioid receptor binding GTPase activating protein binding metal ion binding corticotropin-releasing hormone receptor 1 binding protein binding GDP binding protein complex binding nucleotide binding guanyl nucleotide binding heterotrimeric G-protein
          Process(es)
          protein folding muscle contraction adenylate cyclase-modulating G-protein coupled receptor signaling pathway dopamine receptor signaling pathway Wnt signaling pathway, calcium modulating pathway aging locomotory behavior regulation of heart contraction forebrain development neuron projection development response to cytokine response to drug response to hydrogen peroxide response to morphine positive regulation of GTPase activity negative regulation of calcium ion transport G-protein coupled receptor signaling pathway metabolic process cellular process response to organonitrogen compound response to organic cyclic compound signal transduction
          It has to be done as per old AB suggested Products section.
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