This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene.
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Protein Aliases: glycerate-2-dehydrogenase; Glyoxylate reductase/hydroxypyruvate reductase
Gene Aliases: GLXR; GLYD; GRHPR; MSTP035; PH2
UniProt ID: (Human) Q9UBQ7
Entrez Gene ID: (Human) 9380
Molecular Function: dehydrogenase