|Western Blot (WB)||0.5-1.5 ug/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (QKWTQKKEKGK) corresponding to the internal amino acids of GNRHR|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with canine based on sequence homology.
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone and follicle stimulating hormone . Defects in this gene are a cause of hypogonadotropic hypogonadism . Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GnRH receptor; gnRH-R; GNRHR; GNRHR1; gonadotropin-releasing hormone (type 1) receptor 1; Gonadotropin-releasing hormone receptor; GRHR; leutinizing hormone releasing horomone receptor; leutinizing-releasing hormone receptor; LHRHR; LRHR; luliberin receptor; type I GnRH receptor
Gene Aliases: GNRHR; GNRHR1; GRHR; HH7; LHRHR; LRHR
UniProt ID: (Human) P30968
Entrez Gene ID: (Human) 2798
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