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|Tested species reactivity||Human, Mouse, Primate, Rat|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of human GRK2 expressed in E. Coli.|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||1/200 - 1/1000|
|Immunohistochemistry (IHC)||1/200 - 1/1000|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (Paraffin) (IHC (P))||See 1 publications below|
MA5-15840 targets GRK2 in IF, IHC, and WB applications and shows reactivity with Human, mouse, Non-human primate, and Rat samples.
The MA5-15840 immunogen is purified recombinant fragment of human GRK2 expressed in E. Coli. .
MA5-15840 detects GRK2 which has a predicted molecular weight of approximately 80kDa.
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. Tissue specificity: Expressed in peripheral blood leukocytes
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
A multistep high-content screening approach to identify novel functionally relevant target genes in pancreatic cancer.
MA5-15840 was used in immunohistochemistry - paraffin section to develop a screening strategy to rationally select novel and relevant candidate genes to target therapeutically
|Buchholz M,Honstein T,Kirchhoff S,Kreider R,Schmidt H,Sipos B,Gress TM||PloS one (10:null)||2015|
adrenergic beta receptor kinase 1; adrenergic receptor kinase, beta 1; adrenergic, beta, receptor kinase 1; BARK1, BETA-ARK1, GRK2, G-protein coupled receptor kinase 2; beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase 1 beta ARK1; beta-AR kinase-1; beta-ARK-1; G-protein coupled receptor kinase 2; G-protein-coupled receptor kinase 2
Adrbk-1; ADRBK1; BARK; Bark-1; BARK1; beta ARK; BETA-ARK1; betaARK1; GRK-2; GRK2