PA5-28579 targets GRK 2 in WB applications and shows reactivity with Human samples.
The PA5-28579 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 358 of Human GRK 2.
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The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
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Protein Aliases: adrenergic beta receptor kinase 1; adrenergic, beta, receptor kinase 1; BARK1; Beta-adrenergic receptor kinase 1; Beta-ARK-1; BETA-ARK1; G-protein coupled receptor kinase 2; GRK2
Gene Aliases: ADRBK1; BARK; BARK1; BETA-ARK1; GRK2
UniProt ID: (Human) P25098
Entrez Gene ID: (Human) 156