MA1-2013 detects the beta andrenergic receptor kinase 1 in human, mouse and rat samples.
MA1-2013 has been successfully used in Western blot, immunocytochemistry, immunofluoresence, immunoprecipitation, and ELISA procedures. By Western blot this antibody detects a ~30 kDa protein representing the beta andrenergeic receptor kinase 1 in human HeLa cells. In immunocytochemistry procedures MA1-2013 recognizes the beta andrenergic receptor kinase 1 in HeLa, Hek-293 and 3T3 cells. Immunofluoresence in HeLa cells yeilds predominantely cytoplasmic membrane associated staining with some staining in the ruffles.
The MA1-2013 immunogen is recombinant beta adrenergic receptor kinase 1.
Beta-adrenergic receptor kinase 1 (BARK1) phosphorylates the G-protein coupled b-adrenergic receptor. The b-adrenergic receptor is the primary target of epinephrine in cardiac muscle and other tissues. Elevated levels of BARK1 have been found in failing human heart tissue along with decreased activity of BAR. Knockout studies show that inhibition of BARK1 in Csq mice with severe cardiomyopathy markedly extended lifespan and improve cardiac health. This protein has also been referred to as G Protein Coupled Receptor Kinase 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: adrenergic beta receptor kinase 1; adrenergic receptor kinase, beta 1; adrenergic, beta, receptor kinase 1; Beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase 1 beta ARK1; beta-AR kinase-1; Beta-ARK-1; EC 220.127.116.11; G-protein coupled receptor kinase 2; G-protein-coupled receptor kinase 2
Gene Aliases: Adrbk-1; ADRBK1; BARK; Bark-1; BARK1; beta ARK; BETA-ARK1; betaARK1; GRK-2; GRK2