Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Beta-adrenergic receptor kinase 1 (BARK1) phosphorylates the G-protein coupled b-adrenergic receptor. The b-adrenergic receptor is the primary target of epinephrine in cardiac muscle and other tissues. Elevated levels of BARK1 have been found in failing human heart tissue along with decreased activity of BAR. Knockout studies show that inhibition of BARK1 in Csq mice with severe cardiomyopathy markedly extended lifespan and improve cardiac health. This protein has also been referred to as G Protein Coupled Receptor Kinase 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: adrenergic beta receptor kinase 1; adrenergic receptor kinase, beta 1; adrenergic, beta, receptor kinase 1; Beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase 1 beta ARK1; beta-AR kinase-1; Beta-ARK-1; G-protein coupled receptor kinase 2; G-protein-coupled receptor kinase 2
Gene Aliases: Adrbk-1; ADRBK1; BARK; Bark-1; BARK1; beta ARK; BETA-ARK1; betaARK1; GRK-2; GRK2