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Bioss
GRK4, GRK5, GRK6 Polyclonal Antibody
Product Details
BS-11235R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human GRK6.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-CP4; FP2025; G protein-coupled receptor kinase 2, groucho gene related; G protein-coupled receptor kinase 4; G protein-coupled receptor kinase 5; G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK4; G protein-coupled receptor kinase GRK5; G protein-coupled receptor kinase GRK6; G-protein coupled receptor kinase 6; ITI1; Poly(rC)-binding protein 4
Gene Aliases: 1200003L19Rik; A830025H08Rik; AlphaCP-4; GPRK2L; GPRK4; GPRK5; GPRK6; GRK; GRK4; GRK4a; GRK5; GRK6; IT11; Pcbp4
UniProt ID: (Human) P32298, (Human) P34947, (Human) P43250, (Mouse) O70291, (Rat) P70507, (Mouse) Q8VEB1, (Rat) Q62833, (Mouse) O70293, (Mouse) P57724
Entrez Gene ID: (Human) 2868, (Human) 2869, (Human) 2870, (Mouse) 14772, (Rat) 59077, (Mouse) 14773, (Rat) 59075, (Mouse) 26385, (Rat) 59076, (Mouse) 59092
G-protein coupled receptor kinase activity
ATP binding
rhodopsin kinase activity
protein serine/threonine kinase activity
protein kinase C binding
protein binding
phospholipid binding
beta-adrenergic receptor kinase activity
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
lipid binding
nucleic acid binding
DNA binding
RNA binding
poly(A) RNA binding
RNA metabolism protein
non-receptor serine/threonine protein kinase
G-protein coupled receptor internalization
protein phosphorylation
signal transduction
regulation of G-protein coupled receptor protein signaling pathway
regulation of rhodopsin mediated signaling pathway
receptor internalization
desensitization of G-protein coupled receptor protein signaling pathway
apoptotic process
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
tachykinin receptor signaling pathway
positive regulation of cell proliferation
Wnt signaling pathway
response to drug
negative regulation of apoptotic process
fat cell differentiation
protein autophosphorylation
regulation of cell cycle
negative regulation of anion channel activity
phosphorylation
termination of G-protein coupled receptor signaling pathway
negative regulation of mRNA splicing, via spliceosome
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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