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GRM4 Antibody (CF810384) in IHC (P)
Immunohistochemical staining of paraffin-embedded human embryonic cerebellum within the normal limits using anti-GRM4 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA810384)(1:500)
Product Details
CF810384
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI6D1
Immunogen
Human recombinant protein fragment corresponding to amino acids 126-407 of human GRM4 produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
The Metabotropic Glutamate Receptor mGluR4/GRM4 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G protein-coupled receptor GRM4; G protein-coupled receptor, family C, group 1, member D; glutamate receptor; glutamate receptor, metabotropic 4; Metabotropic glutamate receptor 4; mGluR4
Gene Aliases: GPRC1D; GRM4; mGlu4; MGLUR4
UniProt ID: (Human) Q14833, (Rat) P31423, (Mouse) Q68EF4
Entrez Gene ID: (Human) 2914, (Rat) 24417, (Mouse) 268934
activation of MAPK activity
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
chemical synaptic transmission
neurotransmitter secretion
positive regulation of MAPK cascade
regulation of neuron apoptotic process
regulation of synaptic transmission, glutamatergic
learning
negative regulation of cell proliferation
gamma-aminobutyric acid secretion
neuron projection development
synaptic transmission, glutamatergic
negative regulation of apoptotic process
negative regulation of synaptic transmission
synaptic transmission, GABAergic
signal transduction
G-protein coupled receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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