Sequence of this protein is as follows: CPGYAGLCDA MKPIDGRKLL ESLMKTNFTG VSGDTILFDE NGDSPGRYEI MNFKEMGKDY FDYINVGSWD NGELKMDDDE VWSKKSNIIR SVCSEPCEKG
GRK1 is a member of the guanine nucleotide protein-coupled (G protein) receptor kinase subfamily of Serine/Threonine kinase family. GRK1 phosphorylates rhodopsin and initiates its deactivation. G protein mediated phosphorylation promotes the binding of arrestin, which removes the receptor from the G-protein and terminates the receptor signal chain. GRK1 is farnesylated to promote membrane association. Studies have shown that GRK1 has been shown to be inhibited by recoverin, a Calcium binding protein. Diseases associated with GRK1 protein dysfunction include Oguchi Disease-2 and Hereditary Night Blindness.
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Protein Aliases: A830007B11Rik; D16Ium24; D16Ium24e; Glur-5; Glur5; Glurbeta1; glutamate receptor; glutamate receptor, metabotropic 5; GPRC1A; GRM 1; GRM 5; GRM1; GRM1 alpha; GRM1A; metabotropic 1; Metabotropic glutamate receptor 5; MGC25101; mGlu1; mGluR; mGluR1 alpha; mGluR1A; mGluR5; mGluR5a; protein phosphatase 1, regulatory subunit 86
Gene Aliases: GPRC1E; GRM5; mGlu5; MGLUR5; PPP1R86
UniProt ID: (Human) P41594
Entrez Gene ID: (Human) 2915
Molecular Function: G-protein coupled receptor