|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to C-terminal of human GRP94|
|Storage buffer||PBS, pH 7.6, with 0.2% BSA|
|Contains||15mM sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-16310 targets GRP94 in IHC (P) applications and shows reactivity with Human samples.
The PA5-16310 immunogen is synthetic peptide corresponding to C-terminal of human GRP94.
Heat shock protein (HSP) molecular chaperones are environmental stress inducible gene products. The human HSP 90 family consists of 17 genes classified into four classes: HSP90AA, HSP90AB, HSP90B and TRAP. HSP 90 family members guide the normal folding, intracellular disposition and proteolytic turnover of many key regulators of cell growth, differentiation and survival. GRP 94, glucose regulated protein 94 kDa, a HSP90 family member, (also known as tumor rejection antigen 1 (TRA1), ECGP and GP96), localizes to the ER, is highly expressed in BGC-823 human gastric carcinoma cells and is upregulated in human endothelial cells in response to hypoxia by HIF-1. TRAP1 (TNF receptor-associated protein 1), also designated HSP 75 is a mitochondrial matrix component that plays a role in the induction of apoptosis in response to reactive oxygen species.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.