Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: DGPAGAVLEC LVLSSGMLVP ELAIPVVYLL GALTMLSETQ HKLLAEALES QTLLGPLELV GSLLEQSAPW QERSTMSLPP GLLGNSWGEG APAWVLLDEC GLELGEDTPH VCWEPQAQGR MCALYASLAL LSGLSQEPH
GSDMD (gasdermin-D) promotes pyroptosis in response to microbial infection and danger signals. It is produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as, non-canonical (such as cytosolic LPS) inflammasome activators. After cleavage, GSDMD moves to the plasma membrane where it strongly binds to inner leaflet lipids including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-biphosphate, phosphatidylinositol (3,4,5)-biphosphate, phosphatidic acid, and phosphatidylserine. GSDMD also exhibits bactericidal activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: gasdermin domain containing 1; Gasdermin domain-containing protein 1; Gasdermin-D
Gene Aliases: 1810036L03Rik; AW558049; DF5L; DFNA5L; FKSG10; GSDMD; GSDMDC1; M2-4
UniProt ID: (Human) P57764, (Mouse) Q9D8T2
Entrez Gene ID: (Human) 79792, (Rat) 315084, (Mouse) 69146
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