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Immunogen sequence: TVGLTEDEAI HKYGIENVKT YSTSFTPMYH AVTKRKTKCV MKMVCANKEE KVVGIHMQGL GCDEMLQGFA VAVKMGATKA DFDNTVAIHP TSSEELVTLR
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: epididymis luminal protein 75; epididymis secretory sperm binding protein Li 122m; glutathione reductase; glutathione reductase 1; Glutathione reductase, mitochondrial; glutathione S-reductase; GR; GRase
Gene Aliases: AI325518; D8Ertd238e; GLUR; Gr-1; Gr1; GRD1; GSR; HEL-75; HEL-S-122m
UniProt ID: (Human) P00390, (Mouse) Q8C9Z6
Entrez Gene ID: (Human) 2936, (Mouse) 14782, (Rat) 116686
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