PA5-30052 targets GCS-alpha-3 in WB applications and shows reactivity with Human samples.
The PA5-30052 immunogen is recombinant protein fragment corresponding to a region within amino acids 422 and 638 of Human GCS alpha 3.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit, such as alpha-1 (GUCY1A3), and a beta subunit, typically beta-1 (GUCY1B3; MIM 139397), catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs (Zabel et al., 1998 [PubMed 9742212]).
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Protein Aliases: GC-S-alpha-1; GC-SA3; GCS-alpha-1; GCS-alpha-3; guanylate cyclase 1, soluble, alpha 3; Guanylate cyclase soluble subunit alpha-1; Guanylate cyclase soluble subunit alpha-3; GUC1A3; GUCA3; GUCSA3; GUCY1A1; Soluble guanylate cyclase large subunit
Gene Aliases: GC-SA3; GUC1A3; GUCA3; GUCSA3; GUCY1A1; GUCY1A3; MYMY6
UniProt ID: (Human) Q02108
Entrez Gene ID: (Human) 2982