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Product Details
PA5-103135
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000-1:3,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthesized peptide derived from human GCS beta 2, corresponding to a region within C-terminal amino acids. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.4, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
RRID |
AB_2852505 |
Target Information
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble form, known as GCS or sGC, act as receptors for nitric oxide. The membrane-bound receptor form, known as GC, are peptide hormone receptors. GCS is a cGMP-synthesizing enzyme, which is the major receptor for the neurotransmitter nitric oxide (NO). It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme containing heterodimer, consisting of one 72 kDa alpha subunit and one 65 kDa beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide, which weakly stimulates the enzyme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GCS beta2; GCS-beta-2; GCS-beta2; Guanylate cyclase soluble beta 2 (GTP pyrophosphate - lyase); Guanylate cyclase soluble subunit beta-2; Guanylate cyclase, soluble, beta 2 (GTP pyrophosphate - lyase); soluble guanylate cyclase beta 2a; soluble guanylate cyclase beta 2b; soluble guanylyl cyclase beta2 subunit
Gene Aliases: B930025B03; GC-SB2; Gucy1b2; Gucy1b2a; Gucy1b2b; SGC
UniProt ID: (Rat) P22717
Entrez Gene ID: (Human) 2974, (Rat) 25206, (Mouse) 239134
Molecular Function:
guanylate cyclase
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