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Invitrogen
GUCY1B3 Recombinant Rabbit Monoclonal Antibody (ARC2071)
Product Details
MA5-38086
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
ARC2071
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Guanylyl Cyclase beta 1 (GUCY1B3) (Q02153)
Conjugate
Form
Liquid
Concentration
1.7 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2898004
Product Specific Information
Positive Samples: U-87MG, Mouse lung, Mouse brain, Mouse heart, Rat brain
Immunogen sequence: MYGFVNHALE LLVIRNYGPE VWEDIKKEAQ LDEEGQFLVR IIYDDSKTYD LVAAASKVLN LNAGEILQMF GKMFFVFCQE SGYDTILRVL GSNVREFLQN
Target Information
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta 1 sGC; GCS beta1; GCS beta3; GCS-beta-1; GCS-beta-3; GCS-beta1; GCS-beta3; GCSbeta1; GCSbeta3; guanylate cyclase 1, soluble, beta 3; Guanylate cyclase soluble subunit beta-1; Guanylate cyclase soluble subunit beta-3; guanylate cyclase, soluble, beta 1; NO-sensitive guanylyl cyclase beta 1 subunit; soluble guanylate cyclase beta-1 subunit; Soluble guanylate cyclase small subunit
Gene Aliases: GC-S-beta-1; GC-SB3; GCbeta1; GUC1B3; GUCB3; GUCSB3; GUCY1B1; GUCY1B3; SGC
UniProt ID: (Human) Q02153, (Rat) P20595, (Mouse) O54865
Entrez Gene ID: (Human) 2983, (Rat) 25202, (Mouse) 54195
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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