|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human reb blood cells|
|Storage buffer||tris glycine, pH 7.4|
|Contains||0.09% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay dependent|
|Hemagglutination Assay (HA)||Assay-dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay dependent|
|Western Blot (WB)||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 1 publications below|
MA1-91163 detects CD236R from human samples.
MA1-91163 has been successfully used in immunohistochemistry (frozen tissue), Flow cytometry, and Western blot applications.
The MA1-91163 immunogen is: Human reb blood cells
Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes.
MA1-91163 was used in blocking or activating experiment and flow cytometry to study Plasmodium vivax rosetting and the role of glycophorin C
|Lee WC,Malleret B,Lau YL,Mauduit M,Fong MY,Cho JS,Suwanarusk R,Zhang R,Albrecht L,Costa FT,Preiser P,McGready R,Renia L,Nosten F,Russell B||Blood (123:e100)||2014|