GZMB/GZMH are members of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]
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Protein Aliases: C11; Cathepsin G-like 1; Cathepsin G-like 2; cathepsin G-like 2, protein h-CCPX; CCP-X; CCP1; CGL-2; CGL2; CSP-C; CTLA-1; CTLA1; CTSGL1; CTSGL2; Cytotoxic cell protease 1; cytotoxic serine protease B; Cytotoxic serine protease C; Cytotoxic T-lymphocyte proteinase; Cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; cytotoxin serine protease-C; Fragmentin; fragmentin 2; Fragmentin-2; GLP I; GLP III; GLP-1; granzyme 2; Granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); Granzyme B(G,H); Granzyme H; granzyme H (cathepsin G-like 2, protein h-CCPX); Granzyme-2; granzyme-like protein 1; granzyme-like protein I; GZMH; GZMH/GZMB; HLP; Human lymphocyte protein; Lymphocyte protease; Natural killer cell protease 1; RNKP-1; SECT; T-cell serine protease 1-3E
Gene Aliases: AI553453; CCP-1/C11; CCP-X; CCP1; CCPI; CGL-1; CGL-2; CGL1; CGL2; CSP-B; CSP-C; CSPB; Ctla-1; CTLA1; CTSGL1; CTSGL2; GRB; GZB; GZMB; GZMH; HLP; RNKP-1; SECT