This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
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Protein Aliases: CSE; CTH; CTL target antigen; cystathionase (cystathionine gamma-lyase); Cystathionine gamma lyase; Cystathionine gamma-lyase; cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma cystathionase; Gamma-cystathionase; homoserine deaminase; homoserine dehydratase; PRB-RA; Probasin-related antigen
Gene Aliases: 0610010I13Rik; AI314617; BC019483; CSE; CTH; Cys3; H
Molecular Function: lyase