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Product Details
ABS 017-20-02
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG1, kappa |
Class |
Monoclonal |
Type |
Antibody |
Clone |
20 |
Immunogen |
Gelsolin purified from human plasma. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1.03 mg/mL |
Purification |
Protein A |
Storage buffer |
PBS, pH 7.4 |
Contains |
15mM sodium azide |
Storage conditions |
4° C, store in dark |
RRID |
AB_667468 |
Product Specific Information
ABS 017-20-02 detects Gelsolin from human samples.
ABS 017-20-02 has been successfully used in ELISA and western blot procedures. ABS 017-20-02 does not work as capture antibody in sandwich ELISA.
The ABS 017-20-02 immunogen is a Gelsolin protein purified from human plasma.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
Target Information
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Actin-depolymerizing factor; ADF; ADFBrevin; AGEL; Brevin; DKFZp313L0718; Gelsolin; RP11-477J21.1
Gene Aliases: ADF; AGEL; GSN
UniProt ID: (Human) P06396
Entrez Gene ID: (Human) 2934
Molecular Function:
non-motor actin binding protein
phagocytosis, engulfment
aging
positive regulation of gene expression
oligodendrocyte development
striated muscle atrophy
extracellular matrix disassembly
actin filament polymerization
protein destabilization
tissue regeneration
sequestering of actin monomers
cellular protein metabolic process
actin nucleation
response to ethanol
negative regulation of viral entry into host cell
phosphatidylinositol-mediated signaling
actin filament severing
barbed-end actin filament capping
positive regulation of actin nucleation
response to folic acid
actin filament capping
cilium morphogenesis
cellular response to cadmium ion
regulation of podosome assembly
actin filament reorganization
renal protein absorption
hepatocyte apoptotic process
positive regulation of keratinocyte apoptotic process
regulation of wound healing, spreading of epidermal cells
regulation of establishment of T cell polarity
regulation of plasma membrane raft polarization
regulation of receptor clustering
positive regulation of protein processing in phagocytic vesicle
amyloid fibril formation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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