MA1-24939 detects Gelsolin from human, bovine, porcine, and rabbit samples.
MA1-24939 has been successfully used in immunofluorescence, ELISA and Western blot procedures. The predicted molecular weight is 86 kDa.
The MA1-24939 immunogen is purified, full length, native human protein.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Gelsolin is a calcium dependent actin binding protein. It is a potent modulator of actin filament length and gelation. Gelsolin has been shown to exist in at least two variant forms, cytoplasmic gelsolin and plasma gelsolin. Plasma gelsolin has also been called actin depolymerizing factor (ADF) or brevin. Human plasma and rabbit macrophage gelsolins differ by the presence of a 25 amino acid residue extension at the NH2 terminus in the human plasma gelsolin which appears to account for the difference in relative molecular weights.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Actin-depolymerizing factor; ADF; AGEL; Brevin; Gelsolin; gelsolin (amyloidosis, Finnish type); GSN
Gene Aliases: ADF; AGEL; GSN